Neural Stimulation & Electroceuticals

Sim4Life provides advanced, anatomy-based simulation tools for modeling and analyzing neurostimulation of the central and peripheral nervous system. The platform enables accurate computation of electric fields, current densities, and neural activation, supporting the design, optimization, and safety assessment of neurostimulation therapies.

Read Application Notes
Personalized tPCS Modeling and Neuronal Response Analysis
In Silico Vagus Nerve Stimulator: Design, Optimization, and Safety Evidence Generation
EM-induced Neuronal Dynamics

Overcoming Peripheral Nerve Stimulation in MRI

Peripheral Nerve Stimulation (PNS) remains a key barrier to advancing magnetic resonance imaging (MRI) performance and innovation. Sim4Life helps overcome this with powerful tools:

Advanced "MRI Gradient" solver, for custom coil design
Realistic EM–electrophysiology simulations on neuro-functionalized anatomical models
Automated pulse-shape and coil optimization powered by a flexible Python API

Use Sim4Life to design and test extremity MRI coils – as shown in our example with quantified PNS thresholds for the radial, ulnar, and median nerves – or apply it to a wide range of other MRI applications.

E-Tattoos: Ready to Model Safety & Efficacy

E-Tattoos (see https://spectrum.ieee.org/electronic-tattoo) could transform how we stimulate or record facial nerve activity across a range of applications. With Sim4Life, you can predict safety, optimize performance, and pinpoint the best placement – all through high-fidelity simulations!
Use Sim4Life’s:

Advanced CAD tools, including a projection feature for exact anatomical alignment
Neuro-functionalized anatomical models with subject-specific facial and spinal nerve pathways
Coupled solvers for electromagnetic and electrophysiological analysis

…to design, validate, and accelerate the development of next-generation bioelectronic therapies.
(implant model: courtesy of CorTec)

Safety of WPT-Powered Implants

Curious about how advanced simulations can assess safety in #neurostimulation? In this example, we showcase the safety assessment and effectiveness evaluation of wireless charging of the pulse generator (IPG) of a vagus nerve stimulator (VNS) placed in the chest of a realistic human body model. With Sim4Life, conducting detailed safety assessments and electromagnetic compatibility (EMC) studies is faster, more accurate, and more scalable. Our platform enables high-fidelity simulations to optimize neurostimulation designs – from device modeling to field distribution and tissue interaction.

ECoG Brain Machine Interface

Simulation of intracranial electroencephalography using simplified dipole representations of neural source activity for brain-computer interface applications.

Neural Dynamics of Spinal Cord Stimulation

Identifying the safest and most effective surgical positioning of a new paddle electrode array for spinal cord neuromodulation.

TMS NeuroResponse Analysis

Simulation of the neuroelectric response of cortical pyramidal neurons to supra-threshold transcranial magnetic stimulation (TMS).