Quick-Start Introduction to Cloud Simulations with Sim4Life.web

It’s never been easier to get started in computational life sciences! In this video, Carina, a junior researcher at the IT’IS Foundation, describes how to use Sim4Life.web to perform Tier 4 (ISO 10974) in vivo magnetic resonance imaging implant safety simulations natively in the cloud, with performance similar to that of the locally installed version. Visit www.sim4life.swiss for more information and to create your account!

From Image Data to Thermal Effects and Neurostimulation

In this video, we show how Sim4Life can be used as a computational platform for personalized modeling of transcranial electric and magnetic stimulation. Starting with raw T1 and T2 magnetic resonance imaging data of a person's head, the effects of applying time-varying stimuli to a set of electrodes, are simulated both in terms of temperature rise and neurostimulation. Sim4Life greatly simplify some of the critical bottlenecks in the workflow: creation of the computational model of the head is almost automatic through an AI-assisted Head Segmentation Tool, electrode placement is facilitated by the Electrode Positioning Tool, and pulsation of the low-frequency stimulus from the electrode into the thermal and neuron simulations is conveniently done through amplitude-modulation.
 

In Silico Modeling of Neurovascular Bundle Stimulation in Sim4Life

Sim4Life offers improved functionalities to facilitate the execution of performance and safety-related investigations and predictions in the context of bioelectronics medicine. In this video, we show how Sim4Life can be used to compare the stimulation and the recording performance of endovascular stimulation of neurovascular bundles by two alternative electrode designs.

New Solver-Enhanced Body Models in Sim4Life for Accurate Simulations of 5G NR FR2 Devices

In this video, we show the straightforward simulation setup for mmWave devices with SPEAG’s mmWave hand phantoms, which starts with a simple drag and drop of the phantom's CAD file, followed by automatic assignment of the phantom to a new solver-enhanced material model with parameters obtained from the integrated SPEAG database.

Unleash Your Potential with S4L lite: The Ultimate Tool for Complex Simulations for Students

Meet S4L lite, the new web version of our advanced Sim4Life desktop computational platform for students – the ultimate tool for complex simulations! Say goodbye to laptop performance issues: S4L lite offers equivalent or better performance than Sim4Life Light, in a browser, even on a tablet, without needing to install any software. This video gives an overview of the S4L lite platform's diverse capabilities, from electromagnetic radiation simulation to complex tasks, such as millimeter-wave antenna design and magnetic resonance imaging coil simulation. In S4L lite, projects are accessible anytime, anywhere, and can be easily shared. Completely free for students, including Amazon Web Services resources and time! Visit our website to request a login for the platform.

Enhanced 5G Simulation Toolbox in Sim4Life: Simplified PD Evaluations at 6–10 GHz

ZMT and SPEAG are bringing mmWave simulations and measurements ever closer together, combining the best of both worlds. Electromagnetic (EM) data acquired in the physical world with DASY8/6 Module mmWave can take an active role in the digital world of Sim4Life too!

Sim4Life Neural Sensing Package: Simulation of Neural Activity in a Branching Peripheral Nerve

Sim4Life  permits the straight-forward modeling and simulation of neural sensing applications. The sensing functionalities of Sim4Life are optimized for simulating bioelectric measurements across a variety of scales and structures, including cortical and subcortical signals, EEG, and microelectrode array recordings. In this video we test several of the new Sim4Life tools and features in a realistic model of a branching peripheral nerve with complex fascicular structure.

RF-Induced Heating of a Passive Implant During MRI Scanning

Placement of a knee implant via virtual surgery and coupled FDTD-thermal simulations of exposure to a birdcage coil scaled to the maximum exposure limit.

ECoG Brain Machine Interface

Simulation of intracranial electroencephalography using simplified dipole representations of neural source activity for brain-computer interface applications.

Neural Dynamics of Spinal Cord Stimulation

Identifying the safest and most effective surgical positioning of a new paddle electrode array for spinal cord neuromodulation.

TMS NeuroResponse Analysis

Simulation of the neuroelectric response of cortical pyramidal neurons to supra-threshold transcranial magnetic stimulation (TMS).

Assessment of Compliance, PD & APD

Assessing the compliance of wireless devices with regulatory standards based on metrics such as incident and absorbed power density using Sim4Life simulations.

Impedance Change of Brain Pulsation

Simulating dynamic head impedance changes as a non-invasive surrogate for diagnostic intracranial pressure assessment in Sim4Life.

Personalized Model Creation

Use of the powerful AI-based head segmentation tool in Sim4Life, which creates detailed personalized computational models of the entire head from MRI images within minutes. By placing just four reference points, the user can easily place electrodes on the scalp according to the 10-10 system.

Antenna Design Optimization

Sim4Life provides advanced engineering tools for designing and optimizing antenna performance.

Poser for Any Use Scenario, CTIA Grip

Predicting the performance of a handheld device for any use scenario before manufacturing, using the poser tool in Sim4Life.

Heating of Active Implant during MRI

Radiofrequency-induced heating of an active medical implant during MRI, in the scalp of a detailed anatomical phantom of the IT'IS Foundation Virtual Population, with coupled FDTD-thermal simulations of exposure to a birdcage coil scaled to the maximum exposure limit.

Creation of Sim4Life Pipeline in the Cloud

A web-based pipelining interface allows users to create, edit, and connect computational units for the generation of modular Sim4Life workflows. Shown is a series of Sim4Life-enabled Jupyter notebooks for building and simulating anatomically detailed head models with scalp electrode stimulation.

Tutorial: ISO 10974 Tier 4 Process in Sim4Life

Calculating in vivo power deposition around active implantable medical devices exposed to RF fields follows a tiered approach as outlined in ISO 10974. These tiers range from Tier 1 to Tier 4, each progressively increasing in accuracy and complexity. This tutorial outlines the simulation steps for, the most advanced level, Tier 4, using computational modeling within realistic anatomical environments.

Tutorial: Numerical Estimation of Transfer Function for Homogeneous Tissue in Sim4Life

In the Tier 3 process, as outlined in ISO 10974, the transfer function is a key tool used to assess the safety of medical implants exposed to electromagnetic fields, experienced during MRI. This tutorial outlines the simulation steps to calculate the transfer function numerically using plane wave piecewise excitation of a standard active implantable device (SAIMD).

Tutorial: Helmholtz Coil

A Helmholtz coil setup consists of two identical coils positioned parallel to each other, separated by a distance equal to their radius. When an identical current flows through both coils in the same direction, it creates a uniform magnetic field between them. This tutorial will guide you through the modeling, simulation setup, and analysis of a Helmholtz coil configuration using Sim4Life Lite.

ViP Models with Predefined Postures

The Virtual Population models in Sim4Life are available in predefined postures that reflect common scenarios, such as standing, sitting, driving, holding a phone, and more. These models can be used as-is or can serve as a foundation for customization to meet your requirements for specific in-use or exposure scenarios.

How to model a helix?

The tool under Templates in the ribbon creates a helix around a selected line or spline. The radius of the loops, the distance between loops, the wire radius, the orientation, the initial rotation, and the resolution of this object can be specified in the dialog window.