The Premier Simulation Platform
Device Design. Interactions with Anatomy.
Physiological Responses.
Unmatched Precision. Unrivaled Realism.
Multigoal Optimization.
Performance. Efficacy. Safety.
Verified. Validated. Regulatory Grade.
In Silico We Trust.
On the Desktop.
Natively in the Cloud.
Sim4Life News
ZMT and IT’IS Foundation Bring In Silico to The MedTech Conference 2026
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IT’IS Hosts New Pediatric Model THALIA V1.0
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Hands-On Learning with Sim4Life.lite at URSI GASS 2026
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ZMT, TI Solutions, and IT’IS Foundation Exhibit at 2026 NYC Neuromodulation Conference
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Sim4Life Student Competition 2026
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Powerful Multiphysics CAE for Device Design
Our HPC-accelerated physics solvers excel in managing tens of thousands of intricate 3D elements, surpassing the capabilities of any other commercial solution.
Physics solvers:
- Electromagnetics Full Wave Solvers
- Quasi-Static Electromagnetic Solvers
- Bioheat & Thermodynamics Solvers
- Acoustics & Wave Propagation Solvers
- Fluid Dynamics Solvers
On top of standard engineering tools, users can seamlessly integrate custom-optimized software modules into Sim4Life.web.
Device Interactions in Functionalized 3D Anatomies
Sim4Life integrates the gold standard of computable phantoms for comprehensive population coverage – the Virtual Population (ViP) human phantoms and the Virtual Zoo (ViZoo) animal phantoms.
Properties:
- Sub-mm Resolution
- Hundreds of Tissues, incl. Material Properties
- Dynamic Tissue Models
- Integrated Physiological Information
Physiological Responses to Device Interactions
The integrated tissue and physiology models within Sim4Life empower the assessment of physiological dynamic processes, e.g., for medicine and safety applications.
Physiological tissue models:
- Electrophysiological Neuron Models
- Thermal Tissue Damage Model
- Perfusion and Thermoregulation Models
- Database of Tissue Properties
- Image-Based Heterogeneous and/or Anisotropic Properties
We collaborate with researchers worldwide to collectively advance existing and introduce new tissue models.
Designing Tomorrow’s Medical and Body-Worn Devices
Sim4Life provides top-tier CAD tools and versatile CAD-file importers in any format, alongside specialized tools for seamlessly integrating CAD models with anatomical models and more.
Device Design Tools:
- 3D Spatial or 2D Planar Modeling Tools
- CAD Projection Tool
- 3D Arbitrary Object Array Generation Tool
- Specialized Routing Tools for Implant Lead Trajectories
- Volumetric and Surface Mesh Tools
- Automatic Head Model Segmentation
- Poser & Morphing Tools
Computational device models can be directly validated against their physical prototype using ZMT's and SPEAG's advanced scanning platforms.
Personalized Model Creation for Precision Medicine
Sim4Life includes top-tier tools to convert images (e.g., T1/T2 MRI, CT) into personalized high-resolution multi-tissue models. This process integrates manual and AI-supported segmentation techniques with tissue properties assignment.
Anatomical Model Generation Tools:
- Medical Image Segmentation Tool Set (iSEG)
- AI-Based Anatomical Model Generation
- MRI/CT Image File Importer
- Poser and Morphing Tools
- Model Registration Tools
- 3D Medical Diffusion Tensor Imaging (DTI) Anisotropy
Latest Multi-Dimensional Optimizers for Maximum Performance
Sim4Life includes a large toolbox to optimize device performance and to enhance the efficacy of therapies. From link budget and focus of thermal therapies to targeted neuromodulation and beyond, it offers scientists, engineers, and medical professionals a wide range of possibilities.
List of tools:
- Multi-Objective Genetic Algorithm (MOGA) HyperTool
- Multi-Parameter Multi-Goal Optimizer
- Parameterized Modeling and Sweeper
Verified, Validated and Qualified by Regulators
We work closely with regulators to deliver regulatory grade modeling, covering standardized safety and health risk evaluations and comprehensive risk assessment workflows for MRI implant safety. Sim4Life is the ideal tool to complement clinical studies.
Verified and Validated Tools:
- IMAnalytics with MRIxViP Libraries (MDDT qualified)
- Validated Evaluations of Exposure Metrics (SAR, iPD, APD, etc.)
- Evaluations of Tissue Temperature Increase
- Verified Computational Models
- QA and Test Suites
Specialized Tools and Easy-to-Use Interface
The Sim4Life Framework simplifies multiphysics modeling, covering everything from problem definition and discretization to simulation, analysis, and result visualization. With the powerful Sim4Life Python API, users can automate complex workflows, including geometric modeling, simulation setup, and post-processing, while also enabling the creation of custom tools and standalone applications.
Specialized tools further enhance the capabilities of Sim4Life, streamlining complex tasks and dramatically reducing user effort for advanced applications.
Tools
| Framework
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One Tool, Infinite Applications
Natively in the Cloud or on Your Desktop
Desktop Version: Single Investment for In-House Use
Web Version: Pay-Per-Use, Flexible And Scalable
Work Effortlessly on Any Device
Access, Share, and Collaborate in Real-Time
Work Collaboratively With Your Peers Anywhere, Anytime
Instant Editing, Commenting, Executing, Analyzing, Version Control
Add Your Own Solvers, Post-Processors, Models (coming soon)
Integrate Diverse Expertise for Superior Results